Summary of results from different studies on TAp73's role in angiogenesisa

Model systemReferenceEffect on tumor sizeEffect on angiogenesisVegf-A/angiogenic gene expressionConditions for gene silencing/inducible overexpressionp53 status
In vivoIn vitro
Tumor models
    TPA-DMBA chemical carcinogenesis in TAp73−/− mice11Larger tumorsIncreased
    Eμ-Myc transgenic mouse lymphomagenesis in TAp73−/− mice12Increased
    E1a/Ras-transformed TAp73−/− MEFs in nude/Scid mice12Larger tumorsIncreasedIncreasedIncreased
13Smaller tumorsDecreasedDecreasedWild type
    Xenograft model in nude mice with H1299 cells with TAp73 silencing11Larger tumorsIncreasedIncreasedIncreasedbStableNull
    Xenograft model in nude/Scid mice with H1299/SAOS2 cells with inducible TAp73 expression11Smaller tumors (SAOS2)Decreased (H1299)Long term, from initiation of tumors (5 weeks)Null
13No difference (H1299 and SAOS2)IncreasedIncreased (SAOS2)Transient (6 days after tumor establishment)Null
Other models
    Aorta ring from TAp73−/− mice11Increased
    Retina and iPSC from total p73−/− mice and MSC with p73DD15Decreased in all casesDecreased in retinaDecreased in MSC
    HUVEC cells with p73DD overexpression or total p73 or TAp73 silencing15Decreased (p73DD and total p73 silenced) and no difference (TAp73 silenced)Decreased in all casesTransientWild type
  • a Data from articles that demonstrate an inhibitory role for TAp73 in angiogenesis are in boldface. Data from reports on TAp73 as a positive regulator of angiogenesis are in lightface. A cell without data represents data not provided in the article.

  • b From reference 12.