TABLE 1.

Body composition and tissue-to-body weight ratios of control and muscle-specific Irs1 and/or Irs2 knockout mice

CharacteristicaValue for indicated miceb
Control MKO1MKO1Control MKO2MKO2Control MDKOMDKO
Body weight (g)8.2 ± 0.58.1 ± 0.48.7 ± 0.28.4 ± 0.67.4 ± 0.26.4 ± 0.3*c
Body length (cm)6.6 ± 0.16.5 ± 0.16.6 ± 0.16.4 ± 0.26.3 ± 0.15.7 ± 0.2*
BMD (mg/cm2)0.025 ± 0.0010.025 ± 0.0010.025 ± 0.0010.025 ± 0.0010.024 ± 0.0010.024 ± 0.001
Lean mass (g)6.4 ± 0.46.3 ± 0.36.9 ± 0.26.5 ± 0.46.0 ± 0.25.2 ± 0.2*
Fat mass (g)1.7 ± 0.21.6 ± 0.21.7 ± 0.11.7 ± 0.11.5 ± 0.01.5 ± 0.1
Fat/body (%)20.1 ± 1.120.3 ± 1.620.4 ± 0.620.0 ± 0.520.3 ± 0.622.4 ± 0.6*
Heart/body (%)5.9 ± 0.25.7 ± 0.16.4 ± 0.36.2 ± 0.35.9 ± 0.26.0 ± 0.6
Liver/body (%)37.2 ± 1.839.4 ± 0.734.5 ± 0.832.3 ± 0.735.4 ± 1.234.2 ± 0.9
BAT/body (%)6.6 ± 0.66.8 ± 0.85.6 ± 0.35.0 ± 0.36.0 ± 0.56.6 ± 0.3
WAT/body (%)6.8 ± 1.07.4 ± 0.96.3 ± 0.95.9 ± 1.13.8 ± 0.54.2 ± 0.8
Pancreas/body (%)7.7 ± 0.28.8 ± 0.66.5 ± 0.35.7 ± 0.56.3 ± 0.56.7 ± 0.9
Kidney/body (%)14.7 ± 0.416.2 ± 0.413.3 ± 0.613.2 ± 0.415.6 ± 0.616.3 ± 0.6
Spleen/body (%)5.4 ± 0.66.0 ± 0.45.2 ± 0.45.2 ± 0.44.6 ± 0.35.4 ± 0.3
Lung/body (%)10.4 ± 0.410.6 ± 0.410.3 ± 0.410.4 ± 0.611.6 ± 0.312.4 ± 0.6
  • a BMD, bone mass density; BAT, brown adipose tissue; WAT, white adipose tissue.

  • b Tissues were dissected from the indicated mice (n = 6), and wet weight (± standard error) was measured.

  • c *, P < 0.05.