Table 1

List of proteins that localized to circular dorsal ruffles

Protein(s)Reference(s)
Abl93, 106
Arp 2/347
Cbl83
Cortactin47
Dynamin-247
IRSp5365
MMP293
Nck76
N-WASP51
PAK126, 27
Paxillin, Pyk293
PI3K, PIP3 (nascent), PIP2 (mature)41, 71
Rab550
Rac1, EPS8/Sos/Vav/SWAP7011, 29, 63
Ras50
Src10
WAVE1, WAVE263, 93
WIP20, 51
β1-Integrin46
Crka5, 31, 88
Gab145, 79
mAbp120
MIMb109
Rab5/actinin-4/RN-tre50
SH3YL41
SHIP241
Tuba74
  • a Crk localizes to membrane ruffles.

  • b It is unclear if MIM localizes to CDRs, but it is highly likely, since it binds PIP2 (enriched in CDRs).