Table 2

Comparison between CDRs and podosomes

Comparison categoryCDR characteristic (reference[s])Podosome characteristic (reference[s])
Cell typeMultiple cell types, such as fibroblasts, differentiated epithelial cells, and smooth muscle cells (10)Cells of monocytic lineage (12, 55, 60), smooth muscle cells (35), endothelial cells (67)
StructureRing-like protrusion (93)Ring-like protrusion, occurring as individual puncta or circular clusters (23)
Actin-rich core, together with actin-associated proteins, forming a ring-like structure (10, 93)Actin-rich core (contains actin and actin-associated proteins) surrounded by adhesion proteins (54)
LocationDorsal surface (16, 93)Ventral surface (23)
LifetimeMinutes (10)Minutes (25)
FunctionReceptor internalization (71)Adhesion (52)
Macropinocytosis (51)ECM degradation (14, 33)
Cytoplasmic remodeling (47)Mechanosensor (4, 18)
Cell motility (47, 87)Cell migration (69)
Proteins involvedaArp 2/3 (47)Arp 2/3 (47)
Cortactin (47)Cortactin (47)
WAVE1/2 (93)Talin (59)
WIP (20)Vimentin (19)
Rac (50)Cdc42 (55)
Rab5 (50)Rab7 (112)
Ras (50)Tks5 (21)
  • a For a more comprehensive list of proteins involved in CDR and podosome formation, refer to reference 10.