TABLE 1

Genes differentially expressed upon BYM338 treatment

Probe set identifierGene symbolGene nameFold changeaAdjusted P value
1423261_at1500015O10RikRIKEN cDNA 1500015O10 gene2.312.39E−03
1435605_atActr3bARP3 actin-related protein 3 homolog B (Saccharomyces cerevisiae)2.32.38E−10
1416835_s_atAmd1S-Adenosylmethionine decarboxylase 11.911.45E−06
1452106_atNpntNephronectin1.861.39E−05
1420569_atChadChondroadherin1.825.51E−03
1449824_atPrg4Proteoglycan 4 (megakaryocyte-stimulating factor, articular superficial zone protein)1.72.38E−04
1424268_atSmoxSpermine oxidase1.662.33E−04
1460555_atFam65bFamily with sequence similarity 65, member B1.545.13E−07
1427884_atCol3a1Collagen, type III, alpha 11.486.43E−08
1421186_atCcr2Chemokine (C-C motif) receptor 21.481.48E−03
1423669_atCol1a1Collagen, type I, alpha 11.465.75E−10
1423110_atCol1a2Collagen, type I, alpha 21.461.90E−08
1448424_atFrzbFrizzled-related protein1.458.60E−03
1438009_atHist1h2aeHistone cluster 1, H2ae1.431.08E−04
1423329_atGdap1Ganglioside-induced differentiation-associated protein 11.353.06E−04
1422789_atAldh1a2Aldehyde dehydrogenase family 1, subfamily A21.315.12E−04
1433893_s_atSpag5Sperm-associated antigen 51.292.42E−04
1422847_a_atPrkcdProtein kinase C, delta1.294.22E−10
1418713_atPcbd1Pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 1 (TCF1)1.251.90E−08
1416342_atTncTenascin C1.257.89E−03
1427239_atIft122Intraflagellar transport 122 homolog (Chlamydomonas)1.241.00E−05
1425039_atItgbl1Integrin, beta-like 11.246.11E−04
1416318_atSerpinb1aSerine (or cysteine) peptidase inhibitor, clade B, member 1a1.223.38E−03
1439827_atAdamts12A disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 121.227.55E−07
1451410_a_atCrip3Cysteine-rich protein 31.191.18E−04
1416601_a_atRcan1Regulator of calcineurin 11.154.83E−06
1448328_atSh3bp2SH3 domain binding protein 21.141.90E−08
1459913_atTnfsf10Tumor necrosis factor (ligand) superfamily, member 101.147.85E−04
1434479_atCol5a1Collagen, type V, alpha 11.133.55E−10
1419703_atCol5a3Collagen, type V, alpha 31.127.53E−05
1434411_atCol12a1Collagen, type XII, alpha 11.118.54E−03
1451105_atVash2Vasohibin 21.11.33E−04
1442019_atRcvrnRecoverin1.11.45E−03
1428420_a_at1200009I06RikRIKEN cDNA 1200009I06 gene1.075.20E−04
1434997_atCdk19Cyclin-dependent kinase 191.052.13E−10
1451353_atTm6sf1Transmembrane 6 superfamily member 11.051.47E−05
1460248_atCpxm2Carboxypeptidase X2 (M14 family)1.042.82E−03
1429566_a_atHipk2Homeodomain-interacting protein kinase 21.032.11E−08
1421926_atMapk11Mitogen-activated protein kinase 111.037.47E−05
1425156_atGbp7Guanylate binding protein 71.025.30E−03
1429553_atCilp2Cartilage intermediate layer protein 21.018.92E−03
1448698_atCcnd1Cyclin D11.013.81E−03
1421851_atMtap1bMicrotubule-associated protein 1B11.13E−02
1425631_atPpp1r3cProtein phosphatase 1, regulatory (inhibitor) subunit 3C18.77E−03
1424870_atOsbpl10Oxysterol binding protein-like 100.987.72E−07
1419519_atIgf1Insulin-like growth factor 10.981.96E−07
1460218_atCd52CD52 antigen0.989.29E−03
1444128_atArhgap26Rho GTPase-activating protein 26−1.091.06E−04
1434628_a_atC230052I12RikRIKEN cDNA C230052I12 gene−1.125.02E−09
1417155_atMycnv-myc myelocytomatosis virus-related oncogene, neuroblastoma derived (avian)−1.251.66E−03
1454995_atDdah1Dimethylarginine dimethylaminohydrolase 1−1.377.72E−07
1422580_atMyl4Myosin, light polypeptide 4−1.41.72E−06
1416383_a_atPcxPyruvate carboxylase−1.412.62E−06
1428352_atArrdc2Arrestin domain containing 2−1.442.43E−03
1445186_atStc2Stanniocalcin 2−1.492.67E−05
1418697_atInmtIndolethylamine N-methyltransferase−1.641.95E−04
1447016_atTbc1d1TBC1 domain family, member 1−2.361.88E−06
1432001_atZmynd17Zinc finger, MYND domain containing 17−2.613.92E−04
  • a Fold changes are expressed in log2 scale.