Table 1.

Human cell lines

Cell typeCell line designationDonor age, sexaReplicative life spanKnown abnormalities
Epidermal keratinocyteNNewborn, M∼52 PDNone
N/E7Newborn∼85 PD (extended)HPV16E7+, pRB deficient
LiF-Ep60, F∼35 PDp53+/−
Oral mucosal keratinocyteOKF657, M∼45 PDNone
OKF428, M∼32 PDNone
POE-1965, M∼22 PDNone
Premalignant oral mucosal keratinocytePOE9n65, M∼85 PD (extended)p16−/−, p53 deficient
Dermal fibroblastS1FNewborn, M∼90 PDNone
Peritoneal mesothelial cellLP926, F∼60 PDNone
Epidermal SCCSCC-1356, FImmortalp16 deficient, p53 deficient
  • a M, male; F, female