Table 1.

Sensitivity of MEFs to UV irradiation or cisplatina

MEF lineIC50
UV radiation (J m−2)Cisplatin (μM)
+/+12.0 ± 2.09.0 ± 0.5
gadd45 −/− 7.0 ± 2.04.0 ± 1.0
p21 −/− 8.0 ± 2.54.0 ± 1.0
gadd45/p21-null2.0 ± 1.01.5 ± 0.5
p53 −/− 1.0 ± 0.51.0 ± 0.5
  • a Shown are IC50s of the indicated agents (mean of five or more independent experiments ± standard deviations). Determinations were by 7-day MTT assays.