Table 1.

Liver weights and serum chemistries of conditionally HNF4α-null mice and controlsa

ParameterValue for indicated mouse type
WTAlbCreH4LivKOH4Flox
Liver
 Wet wt (g)0.9 ± 0.10.9 ± 0.21.3 ± 0.3∗∗ 0.8 ± 0.2
 % body wt4.0 ± 0.34.0 ± 0.27.3 ± 0.9∗∗ 3.9 ± 0.1
Serum chemistry
 Albumin (mg/dl)3.8 ± 0.43.8 ± 0.34.0 ± 0.44.0 ± 0.3
 ALT (U/liter)40 ± 2040 ± 2365 ± 7 40 ± 20
 Triglycerides (mg/dl)86 ± 2376 ± 2038 ± 7∗∗ 80 ± 22
 Total cholesterol (mg/dl)119 ± 15114 ± 1448 ± 15∗∗ 121 ± 28
 HDL cholesterol (mg/dl)93 ± 2588 ± 2237 ± 23∗∗ 104 ± 24
 Free fatty acids (mg/dl)1.3 ± 0.41.3 ± 0.41.3 ± 0.21.8 ± 0.9
 Bile acids (μmol/liter)16 ± 717 ± 11283 ± 61∗∗ 10 ± 7
 Glucose (mg/dl)150 ± 32145 ± 2897 ± 39127 ± 36
  • a Mice (45 days old) were fasted for 4 h, anesthetized, and decapitated, and serum was prepared. All values are means ± standard deviations from at least four animals (not separated by sex). Statistics were performed using one-way analysis of variance followed by an unpaired Student t test if applicable. ∗, P < 0.05 ; ∗∗, P < 0.01 . ALT, alanine aminotransferase; WT, wild type.