Table 1.

Neoplasms found in transgenic females carrying the MMTV-CDC37 transgene

PathologyLine% Mice affected (no./total)
Mammary ductal adenosquamous carcinomaMMTV-CDC37.160 (6/10)
MMTV-CDC37.220 (4/20)
LymphomaMMTV-CDC37.150 (5/10)
MMTV-CDC37.220 (4/20)
Mammary ductal adenocarcinomaMMTV-CDC37.110 (1/10)
MMTV-CDC37.20 (0/20)
SarcomaMMTV-CDC37.10 (0/10)
MMTV-CDC37.25 (1/20)
Total affectedMMTV-CDC37.1 a 100 (10/10)
MMTV-CDC37.2 b 45 (9/20)
Nontransgenicc 0 (0/30)
  • a Tumors occurred between 18 and 22 months of age.

  • b All animals were sacrificed and analyzed at 17 months of age without outward signs of transformation.

  • c Animals were examined in parallel with MMTV-CDC37 mice at 17 to 22 months of age.