Table 1.

c-Myc mutations in lymphomas

ResidueMutationOccurrenceOther alleles (occurrence)
E39D11None
A44V6T (1), G (1)
P57S8T (5), A (1)
T58A2
T58I11N (2), D (1)
S62A* 0
S62P3F (2)
S71E* 0
S71F* 0
S71W1None
  • a The frequency of predominant mutations within the Mb1 domain of c-Myc was tabulated from the literature. Other mutations not found in lymphomas (*) but which affect c-Myc phosphorylation were generated for functional analysis in this study.