Table 1.

Time of tumor onset and metastases in MMTV transgenic mice expressing Neu autophosphorylation mutants

StrainAvg age of breast tumor onseta (n)Penetrance of breast tumorsbMetastases (30–60 days with tumor)c
Nulliparous animalsMultiparous animals
NYPD10252 ± 59 (40)163 ± 14 (3)59 (40/68)38 (3/8)
NYPD11255 ± 74 (13)182 ± 65 (2)13 (13/51)0 (0/1)
YB2152 ± 47 (20)170 ± 33 (2)100 (20)50 (2/4)
YB6136 ± 40 (4)268 ± 54 (2)ND100 (1/1)
YD5102 ± 22 (71)109 ± 20 (9)100 (71)10 (3/26)
YD6128 ± 22 (2)274d (1)100 (2)ND
  • a Average age (days) of palpable breast tumor ± standard deviation and (in parentheses) the number of animals with tumors. Nulliparous animals were virgins at the time of breast tumor detection, and multiparous animals had at least one pregnancy.

  • b Penetrance in percent breast tumor phenotype, determined in nulliparous animals. Numbers in parentheses are the number of animals that developed breast tumors within 365 days over the number of observed animals. ND, not determined.

  • c Percentage of animals which possessed lung metastases at time of necropsy and had a palpable breast tumor for more than 30 but less than 60 days prior to necropsy. Numbers in parentheses indicate the number of animals with metastases over the number examined.

  • d This animal was a founder.