Table 1.

Toxicity of anticancer drugs to the elderly correlated with the death pathway they induce in senescent fibroblasts

Anticancer drugaRecommendations of oncologists for use in elderlyDeath pathway induced in fibroblasts
Young cellsOld cells
EtoposideMost often usedApoptosisApoptosis
Cisplatin (high dose)No increased toxicity reportedApoptosisApoptosis
Cisplatin (low dose)Used with acceptable toxicityApoptosisNecrosis
Actinomycin DNot used due to high toxicityApoptosisNecrosis
  • a All the analyzed anticancer drugs are widely used for treatment of young patients.