Table 1.

Regulation of translation by the 3′UTR of the APP mRNAa

Cell typePoly(A) status of APP 3′UTRCAT-L/CAT-SCAT-2G/CAT-SAPP-L/APP-S
Xenopusoocyte2.9 ± 0.4 (n = 5)2.7 ± 0.3 (n = 3)
+1.9 ± 0.3 (n = 3)3
CHO2.2 ± 0.2 (n = 4)3.1 ± 0.6 (n = 3)
+3.3 ± 0.3 (n = 3)4.5
  • a The long or short 3′UTR of APP mRNA or the short 3′UTR with two additional G residues of APP mRNA was cloned downstream the CAT or the APP coding sequence. These mRNAs containing (+) or not containing (−) a poly(A) sequence were translated inXenopus oocytes or in CHO cells. The efficiency of translation is expressed as the ratio of the quantified proteins produced by each of the translated mRNA.