Table 1.

Circulating intermediates in plasma in HNF3βloxP/loxP; Alb.Cre and control micea

IntermediateConcn in plasma in miceReference range (concn)
ControlHNF3βloxP/loxP; Alb.Cre
Creatine phosphokinase (U/liter)2,241 ± 1,4452,114 ± 5740 – 800
Lactate dehydrogenase (U/liter)581 ± 120580 ± 86260 – 680
AST-SGOTb(U/liter)150 ± 36139 ± 2172 – 288
ALT-SGPTc(U/liter)60 ± 2932 ± 424 – 140
Gamma glutamyl transferase (U/liter)0 ± 00.83 ± 0.500 – 2
Amylase (U/liter)2,199 ± 1602,778 ± 303602 – 2,311
Bilirubin, total (mg/dl)0.67 ± 0.450.27 ± 0.050.0 – 0.9
Bilirubin, direct (mg/dl)0.13 ± 0.090.07 ± 0.030.0 – 0.2
Uric acid (mg/dl)4.4 ± 1.91.9 ± 0.22.2 – 4.6
Blood urea nitrogen (mg/dl)21.3 ± 1.419.8 ± 1.59.0 – 28.0
Creatinine (mg/dl)0.38 ± 0.030.33 ± 0.030.2 – 0.7
Albumin (g/dl)2.9 ± 0.52.3 ± 0.42.6 – 4.6
Protein, total (g/dl)4.7 ± 0.23.9 ± 0.44.0 – 6.2
  • a Metabolic parameters were experimentally determined or analyzed by Ani Lytics, Inc., as described under Materials and Methods. Values are represented as means ± standard errors of the means. Comparisons were made among mice of similar age and sex (n = 6 animals for each group).

  • b Aspartate aminotransferase-serum glutamic oxalacetic transaminase.

  • c Alanine aminotransferase-serum glutamic pyruvic transaminase.