Table 2.

High-fat-fed PTP-1B−/− mice have reduced body fat storesa

Genotype (n)Mean carcass composition ± SEM
BW (g)Water (g)LipidFat-free dry mass
g% BWg% BW
WT (7)40.57 ± 3.81a 18.84 ± 1.12a 8.43 ± 1.24a 19.96 ± 1.40a 13.30 ± 1.54a 32.44 ± 0.94a
PTP-1B+/−(5)36.60 ± 3.14a 18.24 ± 0.98a,b 6.82 ± 1.38a 17.72 ± 2.24a 11.54 ± 0.93a 31.74 ± 1.21a,b
PTP-1B−/−(9)25.33 ± 1.44b 15.38 ± 0.81b 2.40 ± 0.41b 8.97 ± 1.34b 7.56 ± 0.39b 29.98 ± 0.37b
  • a Male PTP-1B−/−, PTP-1B+/−, and WT mice were fed a high-fat diet ad libitum for 16 weeks. Body weight (BW) and food intake were measured weekly. Mice were killed at 20 weeks of age, and total carcass fat (triglycerides), fat-free dry mass, and water content were determined. Values in the same column not sharing a superscript letter are significantly different (P < 0.05).