Table 1.

High-fat-fed PTP-1B−/− mice have reduced fat pad massa

Genotype (n = 5)Mean fat pad mass ± SEM
EpididymalInguinalSubcutaneousInterscapularBAT
WT1.968 ± 0.183a 1.050 ± 0.153a 0.418 ± 0.104a 0.278 ± 0.020a 0.081 ± 0.014a
PTP-1B−/− 0.666 ± 0.118b 0.318 ± 0.097b 0.108 ± 0.048b 0.071 ± 0.034b 0.080 ± 0.007a
  • a Male PTP-1B−/− and WT mice were fed a high fat-diet ad libitum for 16 weeks. Body weight and food intake were measured weekly. Mice were killed at 20 weeks of age, and the mass of individual fat pad depots was determined. Values in the same column not sharing a superscript letter are significantly different (P < 0.05).