Table 1.

Impact of PARP and p53 deficiency on chromosomal integrity and telomere function

GenotypeTotal no. of metaphases analyzed% of chromosome aberrationsaNo. of undetectable TTAGGG repeatsbTelomere fluorescence (TFU) (mean ± SE)
PARP p53 Aneuploid cells End-to-end fusions Fragments p-arm q-arm All
+/++/+ 16 0 (0) 0 (0) 0 (0) 0 (0)35 ± 0.3 48 ± 0.441 ± 0.2
+/+ +/− 16 6 (1) 6 (1R)13 (2AC) 3 (0.1) 35 ± 0.5 49 ± 0.642 ± 0.4
−/− +/+ 16 19 (3) 31 (1RL, 2R, 2DIC) 44 (5AC, 1CT, 1CH) 13 (0.5) 25 ± 0.231 ± 0.4 28 ± 0.2
−/− +/− 32 28 (9)53 (7RL, 5R, 2DIC) 69 (6C, 12AC, 3CT, 1CH) 37 (0.7)30 ± 0.5 55 ± 1.1 43 ± 0.6
+/+ −/−59 27 (16) 47 (14RL, 8R, 6DIC) 68 (11C, 22AC, 4CT, 3CH) 61 (0.7) 35 ± 0.5 49 ± 0.6 42 ± 0.4
+/− −/− 33 21 (7) 36 (4RL, 5R, 3DIC)21 (1C, 6AC) 21 (0.4) 44 ± 0.5 62 ± 0.953 ± 0.6
−/− −/− 72 40 (29) 92 (37RL, 14R, 15DIC) 50 (7C, 18AC, 5CT, 6CH) 73 (0.8) 50 ± 0.779 ± 1.3 65 ± 0.8
  • a Information in parentheses indicates scored chromosome abnormalities. RL, Robertsonian-like configurations; R, ring-like chromosomes; DIC, dicentric chromosomes; AC, acentric chromosomal fragments; C, centric chromosomal fragments; CT, chromatid breaks; CH, chromosome breaks.

  • b Values in parentheses indicate signal-free ends per total ends.