Table 2.

Summary of tumor types in PARP p53 double-mutant mice

Genotype of mice No. of mice analyzedNo. of tumors analyzedTumor typeaNo. of tumors
PARP p53
+/+ −/− 26 31Lymphoma 22
Sarcoma 7
Teratoma 2
+/− −/− 28 39 Lymphoma 16
Sarcoma 16
Primitive neuroectodermal tumor 1
Colon adenocarcinoma 3
Hepatocellular carcinoma 1
Squamous cell carcinoma 1
Mammary gland carcinoma 1
−/− −/− 33 45Lymphoma 21
Sarcoma 13
Teratoma 2
Primitive neuroectodermal tumor 5
Pancreatic carcinomas 2
Colon adenocarcinoma 1
Undifferentiated adenocarcinoma 1
+/+ +/− 10 12Lymphoma 4
Sarcoma 7
Ependymoma 1
+/−+/− 35 43 Mammary gland carcinoma 6
Prostate adenocarcinoma 5
Squamous cell carcinoma 2
Lung adenocarcinoma 2
Hepatocellular carcinoma 2
Ependymoma 1
Lymphoma 7
Sarcoma 17
Teratoma 1
−/− +/− 3354 Mammary gland carcinoma 9
Prostate adenocarcinoma 3
Lung adenocarcinoma 6
Squamous cell carcinoma 4
Ependymoma 3
Lymphoma 6
Sarcoma23
  • a Carcinomas and brain tumors are shown in boldface.