Table 3.

Summary of cytogenetic changes and telomere fluorescence in normal thymocytes and thymic lymphomas

SampleGenotypeChromosome aberrationsaTelomere fluorescence (TFU) (mean ± SE)
PARP p53 % of fusionsb% of fragmentsbNo. of chromosomes/ metaphase (mean ± SE) p-arm q-arm All
Normal thymocytes
 C97+/+ +/+ 0 (0) 0 (0)40 ± 0.0 33 ± 0.444 ± 0.5 38 ± 0.3
 B84 +/− +/+ 0 (0)0.1 (1) 40 ± 0.1 37 ± 0.4 45 ± 0.541 ± 0.4
 B11 +− +/− 0 (0) 0.1 (1)40 ± 0.1 39 ± 1.3 51 ± 1.8 44 ± 1.1
 A21 −/− +/− 0.2 (2) 0.2 (3) 41 ± 0.838 ± 1.3 45 ± 1.8 42 ± 1.1
 B88 +/−−/− 0 (0) 0.2 (1) 40 ± 0.2 53 ± 1.264 ± 1.6 58 ± 1.3
 A14 −/− −/−0.2 (2) 0.5 (5) 40 ± 0.4 52 ± 1.465 ± 2.1 59 ± 1.3
Thymic lymphomas
 AP35 −/− +/−1.6 (18) 1.4 (15) 59 ± 2.4 25 ± 0.626 ± 0.6 25 ± 0.4
 TL65 +/− −/−0.7 (8) 0.3 (3) 54 ± 1.4 17 ± 0.322 ± 0.6 19 ± 0.2
 TL76 +/− −/−1.2 (12) 0.4 (4) 52 ± 3.8 21 ± 0.423 ± 0.4 22 ± 0.3
 AP6 +/− −/−0.3 (3) 0.1 (1) 66 ± 5.3 25 ± 0.528 ± 0.6 26 ± 0.4
 AP77 +/− −/−0.1 (1) 0.4 (4) 50 ± 1.6 37 ± 0.743 ± 0.8 40 ± 0.6
 AP86 −/− −/−0.3 (3) 0.0 (0) 76 ± 2.8 45 ± 0.747 ± 0.8 46 ± 0.5
  • a At least 10 metaphases from each sample were scored.

  • b Values in parentheses indicate scored chromosome abnormalities.