Table 1.

Summary of results of BMT experimentsa

Notch1 constructMiceOnset (days)
No. transplantedNo. developing leukemiaMeanRange
ICN664723–55
ΔW16167726–107
ΔRAM886750–75
ΔRAMΔP15158975–172
Δ(N-TAD-P)80423NA
ΔANK120242NA
ΔRAMΔOP160375NA
ΔRAMΔTAD50419NA
ANK80242NA
ΔRAMΔ(TAD-P)50390NA
  • a Mean onset indicates the time period that mice were followed posttransplantation without the development of leukemia. The development of leukemia was defined by the detection of CD4+-CD8+ T cells in peripheral blood. NA, not applicable.