Table 1.

Summary of cyclin E-Cy motif mutant interactions

Cy motifp21Substrate promotes phosphorylation
Inhibition of E/K2a in vitroInhibition of cell growthAssociation with cyclin E in vitroAssociation with E/K2 in vitro
RRLFG+++++++++++
ΔCy
VRLFG++++++++
WRLFG++
  • a E/K2, cyclin E-cdk2.