Table 1.

Compilation of nonredundant set of 113 vertebrate PTPsa

NameSubtypeHuman orthologFull-length nameSynonym(s)Swiss-Prot GenBank accession no.
Non-RPTP subtypes
 hPTP1BNT1PTP1BPTP-1, PTP-1B P18031 M31724, M33689,
 mPTP1BNT1PTP1BPTP1BPTP-1, HA2, PTP-HA2 P35821 U24700, Z23057, M97590,L40595
 rPTP1BNT1PTP1BPTP1BPTP-1 P20417 M33962
 cPTP1BNT1PTP1BPTP1B O13016 U86410
 zPTP1BNT1PTP1BPTP1B AF097481,AF097482, AF097483
 hTCPTPNT1TC-PTP (T-cell phosphatase)PTP-2 P17706 M25393, M81478, M80737
 mTCPTPNT1TCPTPTC-PTP (T-cell phosphatase)PTP-2 O06180 S52655, M81477, M80739
 rTCPTPNT1TCPTPTC-PTP (T-cell phosphatase)PTP-2, PTP-S P35233 X58828
 hSHP1NT2Src homology domain 2-containing PTP1SH-PTP1, SHP, HCP, PTP1C P29350 M74903, X62055, M77273,M90388, X82817, X82818
 mSHP1NT2SHP1Src homology domain 2-containing PTP1 P29351 M68902, M90389, U65953,U65954, U65955
 rSHP1NT2SHP1Src homology domain 2-containing PTP1 U77038
 hSHP2NT2Src homology domain 2-containing PTP2SH-PTP2, SH-PTP3, Syp, PTP-2C, PTP1D O06124 D13540, L03535, L07527, X70766, L08807, S78088,S39383
 mSHP2NT2SHP2Src homology domain 2-containing PTP2SH-PTP2, Syp P35235 L08663, D84372
 rSHP2NT2SHP2Src homology domain 2-containing PTP2PTP-1D P41499 U09307, U05963,D83016
 cSHP2NT2SHP2Src homology domain 2-containing PTP2SH-PTP2, Syp U38620
 xSHP2NT2SHP2Src homology domain 2-containing PTP2 U15287
 hMEG2NT3Megakaryocyte-PTP2 P43378 M83738
 mMEG2NT3MEG2Megakaryocyte-PTP2 AF013490
 xPTPX1NT3b L33098
 xPTPX10NT3 L33099
 hPESTNT4Pro, Glu, Ser, Thr-rich PTPPTP-PEST, PTPG1 O05209 D13380, M93425,S69184
 mPESTNT4PESTPro, Glu, Ser, Thr-rich PTPPTPP19 P35831 X86781, X63440,S36169
 rRKPTPNT4PESTRat kidney PTP D38072
 hLyPTPNT4Lymphoid phosphataseLyP1, LyP2 AF001846, AF001847, AF077031,AF150732
 mPEPNT4LyPTPHematopoietic cell PTP P29352 M90388
 hBDP1NT4Brain-derived phosphatase 1 X79568
 rPTP20NT4BDP1 U69673
 mPTPK1NT4BDP1PTPFLP1 (fetal liver phosphatase 1) U35124, U52523,U49853
 hMEG1NT5Megakaryocyte-PTP1PTPG1, PTPF36-15 P29074 M68941,AAB26477
 mPTPtepNT5MEG1Testis-enriched phosphatasePTPMEG AF106702
 zPTPH1NT5MEG1 AF097477,AF097478, AF097479,AF097480
 hPTPH1NT5PTPH1 P26045 M64572,S39392
 mPTPRL10NT6PTPD1 Q62136 D37801,D83072
 rPTP2ENT6PTPD1PTPD1 Q62728 U17971,U18293
 hPTPD1NT6PTPD1PTPD1 Q16825 X79510
 hPTPD2NT6PTPD2PEZ (phosphatase ezrin-like) Q15678 X82676
 mPTP36NT6PTPD2PTPD2 Q62130 D31842
 hPTPBASNT7FAS-associated PTP1BAS, PTP1E, PTPE1, FAP-1, PTPL1, CD95 Q12923 X80289,U12128, D21209, D21210, D21211, U81561, X79676
 mPTPBLNT7PTPBASDPZPTP, PTPRIP D28529,Z32740,D83966
 bPTPBA14NT7PTPBAS U20807
 hPTPTypNT8Testis-specific tyrosine phosphataseTyp AL050040
 mPTPTypNT8PTPTypTestis-specific tyrosine phosphataseTyp D64141
 hHDPTPNT9His domain-containing PTPHD-PTP, PTPTD14 T14756, AB025194, AB040904,AL110210,AF169350
 rPTPTD14NT9HDPTP AF077000
RPTP subtypes
 hCD45R1/R6Cluster of differentiation 45Leukocyte common antigen (LCA), T200, PTPRC P08575 Y00638,Y00062
 mCD45R1/R6CD45Cluster of differentiation 45LCA, T200, Ly5 P06800 M14342, M92933,M33482
 rCD45R1/R6CD45Cluster of differentiation 45Leukocyte common antigen P04157 M10072, Y00065, M25820,M25821, M25822, M25823, K03039
 cPTPlambdaR1/R6CD45PTPlambda L13285,Z21960
 xCD45R1/R6CD45Cluster of differentiation 45 AF024438
 hPTPlambdaR2ARPTPlambdaPCP2, PTPomicron, PTPfmi, PTPpi, PTPi, PTPRO Q92729 U60289, X97198,U73727, U71075,X95712, AL049570
 mPTPlambdaR2APTPλRPTPlambdaPTPftp1, PTPpsi U55057, D88187
 rPTPpsiR2APTPIRPTPpsi U66566
 hPTPkappaR2ARPTPkappa Q15262 L77886,Z70660
 mPTPkappaR2APTPκRPTPkappa P35822 L10106
 hPTPmuR2ARPTPmu P28827 X58288
 mPTPmuR2APTPmRPTPmu P28828 X58287
 hPTPrhoR2ARPTPrho AF043644,AL024473, AL022239,Z93942
 mPTPrhoR2APTPrRPTPrho AF152556
 xPTPrhoR2APTPrRPTPrho AF173857
 hLARR2BLCA-related PTPc PTP-LAR P10586 Y00815
 mLARR2BLARLCA-related PTP PTP-LAR Z37988
 rLARR2BLARLCA-related PTP PTP-LAR L11586, U00477, X83546,X83505
 xLARR2BLARLCA-related PTPPTP-LAR AF197945
 hPTPdeltaR2BRPTPdelta P23468 X54133,L38929
 mPTPdeltaR2BPTPδRPTPdelta D13903
 cLARR2BPTPδCRYPalpha L32780
 xPTPdeltaR2BPTPδRPTPdelta AF197944
 hPTPsigmaR2BRPTPsigma U35234,U40317, U41725, AC005788, S78080,S78086
 rPTPsigmaR2BPTPςRPTPsigmaLAR-PTP2, PTP-PS, PTP-P1 L11587,AF073999
 mPTPNU3R2BPTPςPTPsigma, PTPT9a, PTPT9b X82288, D28530,D28531
 xCRYPalphaR2BPTPς AF198450
 hPTPS31R3 I32038,I32036, I32037, I32035,I32039
 rPTPGMCR3PTPS31Glomerular mesangial cell receptorPTPRQ, PTPGMC1 AF063249
 hGLEPP1R3Glomerular epithelial protein 1PTPU2, PTProt U20489,Z48541
 mPTPphiR3GLEPP1PTP-BK, PTP-ro, mGLEPP1 U37465, U37466, U37467,AF295638
 rPTPBEM1R3GLEPP1Brain-enriched membrane-associated PTP1PTPD30, BSM-1 D45412,U28938
 rabPTPocR3GLEPP1Osteoclastic PTP U32587
 cPTPcryp2R3GLEPP1CRYP-2 U65891
 hPTPbetaR3RPTPβ P23467 X54131
 mPTPbetaR3PTPβVascular endothelial PTP (VE-PTP) X58289,AF157628
 hDEP1R3Density-enhanced PTPPTPeta, CD148, F-36-12 Q12913 U10886, D37781,AAB26475
 mPTPBYPR3DEP1RPTPbeta-like PTPPTPeta Q64455 D45212
 rDEP1R3DEP1Density enhanced PTPVascular PTP-1 U40790
 hSAP1R3Stomach cancer-associated PTPhPTPH D15049,AAF91411
 rPTPBEM2R3SAP1Brain-enriched membrane-associated PTP2 D45413
 mPTPespR3Embryonic stern cell PTPOST-PTP P70289 U36488,AF300701
 rOSTPTPR3Osteotesticular PTP O64612 L36884
 hPTPalphaR4RPTPalpha P18433 M34668,X54130, X54890,X53364
 mPTPalphaR4PTPαRPTPalphaLCA-related PTP P18052 M36033, M33671,M36034
 rPTPalphaR4PTPαRPTPalpha Q03348 L01702
 cPTPalphaR4PTPαRPTPalpha Z32749,L22437,
 xPTPalphaR4PTPαRPTPalpha U09135
 hPTPepsilonR4RPTPepsilon P23469 X54134
 mPTPepsilonR4PTPɛRPTPepsilon P49446 U35368,U36758, D83484, U62387,U40280
 rPTPepsilonR4PTPɛRPTPepsilon D78610,D78613
 hPTPgammaR5RPTPgamma P23470 L09247,X54132
 mPTPgammaR5PTPγRPTPgamma Q05909 L09562
 cPTPgammaR5PTPγRPTPgamma Q98936 U38349
 cPTPzetaR5RPTPzeta L27625
 hPTPzetaR5PTPζRPTPzeta P23471 M93426,X54135,U88967
 rPTPzetaR5PTPζRPTPzeta Q62656 U09357
 hPCPTP1R7PC12-derived PTPPTPch1g, PTPCOM1, hCh1PTPα, PTPEC D64053, U77916,U77917, U42361, X82635, Z79693
 rPCPTP1R7PCPTPPC 12-derived PTPPC12-PTP1, CBPTP D38292, D64050,U14914
 mPTPSLR7PCPTPPTPBR7, PTP-SL, PC 12-PTP1 Z30313, AF041866,D31898
 hSTEPR7Striatum-enriched phosphatase P54829 U27831
 mSTEP61R7STEPStriatum-enriched phosphatase P54830 U28217, S80329,U28216
 rSTEPR7STEPStriatum-enriched phosphatase P35234 S49400
 hHePTPR7Hematopoetic PTPLeucocyte PTP P35236 M64322,D11327
 rLCPTPR7HePTPLeukocyte PTPHematopoetic PTP P49445 U28356
IRL subtyped
 hPTPIA2R8Islet cell antigenIslet cell antigen, ICA-512 Q16849 L18983,Z48226, X62899
 mPTPIA2R8IA2Islet cell antigenPTP35 Q60673 U11812,X74438
 rPTPIA2R8IA2Islet cell antigenBEM-3, PTPN, ICA105, PTPLP Q63259 D45414, X92563, D38222,U40652
 bPTPIA2R8IA2Islet cell antigenICA512 P56722 AF075170
 hPTPIA2betaR8PTP-IA-2betaIAR, RPTPX Q92932 U65065, AF007555, L76258, U81561,AB002385
 mPTPNPR8IA2βNervous system and pancreatic PTPIA2beta, RPTPX, PTPNP-2 P80560 U57345
 macPTPIA2betaR8IA2βIA2beta O02695 U91574
 rPTPNE6R8IA2βIA2beta, phogrin Q63475 U73458, Z50735
  • a Summary of vertebrate PTP database entries showing nomenclature and accession numbers assigned to each PTP. The PTP name is that most frequently used in the PubMed literature database. The letters preceding the PTP name represent the following: b, bovine; c, chicken; h, human; m, mouse; mac, monkey; r, rat; rab, rabbit; x, xenopus; z, zebra fish. Entries (either Swiss-Prot or GenBank) were used for the primary amino acid sequence alignment of PTP domains (Fig. 1). The PTP entries are grouped according to catalytic domain sequence similarity and have been classified into 17 PTP subtypes: nine nontransmembrane (NT1 to NT9) and eight receptor types (R1/R6, R2a, R2b, R3, R4, R5, R7, and R8). The basis for this classification is detailed in the legend to the homology tree in Fig.2. The existing nomenclature for RPTP subtypes was used since these have previously been classified into almost identical groups based on extracellular domain similarity (8). Ortholog pairs of proteins were identified from the phylogentic analysis (Fig. 2). Note that RPTP subtypes R3, R4, and R7 include both transmembrane and cytoplasmic enzymes (see text for details). An electronic version of this table can be retrieved (http://science.novonordisk.com/ptp), in which the accession numbers are hyperlinked to the NCBI website and PubMed literature database (http://www.ncbi.nim.nih.gov).

  • b —, no obvious human ortholog identified.

  • c LCA, leukocyte common antigen.

  • d IRL, IA2 receptor-like.