TABLE 1.

In vivo inactivation of Nck1 and Nck2 results in embryonic lethality at E9.5a

Dissection time point (day)No. of surviving embryos or mice from Nck1−/− Nck2+/− × Nck1+/− Nck2−/− intercrosses
Nck1+/− Nck2+/−Nck1−/− Nck2+/−Nck1+/− Nck2−/−Nck1−/− Nck2−/−
P216157510
E121214110
E102522277
E830312629
  • a Loss of in vivo function of either Nck1 or Nck2 does not result in any gross morphologic or functional abnormalities. In contrast, mutation of both Nck1 and Nck2 genes is incompatible with a normal embryonic development and results in death in utero at around gestational day 9.5. P, postnatal day.