TABLE 1.

Summary of known interactions among early exchange genes

GeneInteraction(s)Method (reference)Expression
MRE11 Mre11p-Mre11p, Mre11p-Rad50p, Mre11p-Xrs2pTwo-hybrid analysis (22), coimmunoprecipitation (47)Mitotic/meiotic
RAD50 Rad50p-Mre11pTwo-hybrid analysis (22), coimmunoprecipitation (47)Mitotic/meiotic
XRS2 Xrs2p-Mre11p, Xrs2p-Rad50pTwo-hybrid analysis (22), coimmunoprecipitation (47)Mitotic/meiotic
REC103 Rec103p-Spo11pTwo-hybrid analysis (48)Mitotic/meiotic
MER2/REC107 UnknownMeiotic/meiotic
MER1 UnknownMeiotic
MRE2/NAM8 UnknownMitotic/meiotic
REC102 Spo11p-Rec102p, REC104-REC102 Coimmunoprecipitation (23), high-copy-number-suppression (42)Meiotic
ME14 UnknownMeiotic
REC104 REC104-REC102 High-copy-number suppression (42)Meiotic
REC114 UnknownMeiotic
SPO11 Spo11p-Rec102p, Spo11p-Rec103pCoimmunoprecipitation (23), two-hybrid analysis (48)Meiotic