TABLE 2.

UPR target genes induced by XBP-1s

Fold change in expression with:GenBank no.Description
XBP-1sWTXBP-1−/−
5.79.6NCAI835630ERdj4
2.9∼4.0NCAW212878EDEM
2.73.63.1AW122364Armet
2.73.3NCAI604013p58IPK
3.22.7NCU28423p58IPK
2.21.7NCAW045202PDI-P5
2.11.5NCAI843466Ramp4
1.92.1NCAW122551HEDJ
2.24NCAW123880XBP-1
1.81.7NCAI117848mgat2
3.2117.2AI846938Herp
2.47.42D16333Coproporphyrinogen oxidase
28.8∼15.0AW124049EST
1.94.6NCAI845538MGP
1.52.4NCAI843342Splicing factor, arginine/serine-rich 1
1.91.7NCAV318100Similar to glucosidase 1
1.71.9NCM22998Solute carrier family 2, member 1
1.61.6NCM73329Phospholipase Cα
1.61.6NCAI839280RIKEN cDNA 1810045K07 gene
1.52.5NCAW123026Glucosamine-phosphate N-acetyltransferase 1
2.11.52.2X83601Pentaxin related gene
1.74.52.8AJ002387BiP
1.61.9NCAA170696Intercellular adhesion molecule
1.62.2NCAI316859Hypothetical protein LOC223770, BR-140L
1.52.92.3V00756Interferon-related developmental regulator 1
1.51.8NCX92665Ubiquitin-conjugating enzyme E2E 1
  • a Genes that were induced by doxycycline removal in MEF-tet-off-XBP-1s cells, as well as by Tm treatment in wt MEF cells are shown. Genes were sorted by ratio of positive oligonucleotide probe pairs upon doxycycline removal in MEF-tet-off-XBP-1s cells, and the genes that were as also inducible by Tm in wt cells are shown. Values represent the fold changes in expression level. NC, no change.