TABLE 2.

Comparison of survival of frk/rak-null mice after exposure to single doses of ionizing radiationa

Dose (Gy)% Survival ± SEM on day 10 (n) of genotype:Statistical significance
+/++/−−/−
1152.2 ± 27.2 (13)53 ± 18.4 (31)59.5 ± 13.4 (23)0.80b
0.84c
0.68d
1082.3 ± 16.6 (25)78.7 ± 11.2 (37)69.9 ± 21.2 (31)0.75b
0.69c
0.37d
9100 (21)100 (25)87.5 ± 2.2 (25)N/Ab,e
0.24c
0.23d
  • a Data is cumulative from two separate trials (9 and 11 Gy) and three separate trials (10 Gy). Cohorts consist of 9.5- to 11-week-old age-matched littermates generated by heterozygous intercrosses with nearly 50% male and females.

  • b P value for +/+ versus +/− mice is given.

  • c P value for +/− versus −/− mice is given.

  • d P value for +/+ versus −/− mice is given.

  • e N/A, not applicable.