TABLE 2.

Absolute number and frequency of hematopoietic stem cells in transplanted animalsa

Time posttransplant (mo)AML1-ETO/GFP mice Control GFP mice Average expansion (fold)
Absolute HSC no.Frequency of HSC (%)Absolute HSC no.Frequency of HSC (%)
27,7550.0171,5090.004
10,8020.0182,3260.0073
5,8950.015
1093,9600.1166,1620.011
118,5560.16310,2000.02029
505,2000.800
2.5b 52,1000.14610,9800.015
16,4800.03210,8900.0159
259,9800.61913,5300.022
  • a Hematopoietic stem cells were derived from the femurs and tibias of transplanted mice. Average expansion is a multiple of the average number of HSC in AML1-ETO-transplanted animals over the average number in control GFP-transplanted animals at a given time point.

  • b Animals from whole bone marrow transduction.