TABLE 1.

Genotyping analysis of progeny from Mdm4 heterozygous intercrosses

StageNo. of littersTotal no. of embryosNo. of embryos with Mdm4 genotypeNo. with growth defect/abn.a−/− (%)bNo. of resorbing embryosc
+/++/−−/−
E9.52146443290
E10.521731044240
E11.56491424119182
E12216275164
E12.5215681001
E13.53225160000
F2128832560
  • a Number of embryos with a growth defect or abnormality.

  • b Percentage of embryos with Mdm4−/− genotype.

  • c All resorbing embryos were identified as Mdm4 homozygous mutants