TABLE 1.

Litter size, embryo and body weights, fat pad weights, lipid metabolites, and total lipid contents in livers of wild-type and Pref-1-null micea

VariableSexMouse group
Wild typePref-1 null
Litter size (no. of pups/litter)6.75 ± 0.32 (27)4.26 ± 0.26 (25)d
Body wt (g)
    E18.51.18 ± 0.003 (12)0.96 ± 0.004 (9)d
    3 wkFemale8.51 ± 0.19 (27)7.34 ± 0.21 (32)d
Male8.81 ± 0.91 (27)7.58 ± 0.25 (37)d
    16 wkFemale25.35 ± 0.50 (11)24.94 ± 0.99 (14)
Male35.72 ± 0.37 (16)35.60 ± 0.97 (14)
Fat pad wt (% of body wt)b
    8 wkFemale3.33 ± 0.62 (10)3.80 ± 0.37 (7)
Male3.12 ± 0.34 (4)3.17 ± 0.33 (7)
    16 wkFemale4.32 ± 0.38 (7)6.70 ± 0.50 (9)e
Male6.69 ± 0.49 (7)8.39 ± 0.29 (7)e
Blood metabolites
    Triglycerides (mg/liter)Female8.82 ± 0.70 (5)12.0 ± 1.20 (6)f
Male11.1 ± 0.70 (5)19.6 ± 2.30 (6)e
    Cholesterol (mg/liter)Female8.37 ± 0.63 (5)11.7 ± 1.34 (6)f
Male13.2 ± 0.54 (5)16.94 ± 0.85 (6)e
    Free fatty acids (mmol/liter)Female1.56 ± 0.08 (5)1.79 ± 0.10 (6)
Male1.66 ± 0.14 (5)2.23 ± 0.18 (6)f
Lipid content in liver (mg/g of liver)cFemale5.76 ± 0.31 (7)8.77 ± 0.57 (4)e
Male8.35 ± 0.44 (5)10.73 ± 0.69 (5)f
  • a Values represent the average ± standard error of the mean. The number of samples is in parentheses.

  • b The fat pad weights represent inguinal, retroperitoneal, and reproductive fats from mice 8 or 16 weeks of age.

  • c Total lipid was extracted with a mixture of hexane-2-propanol(3/2 ratio) from mice 16 weeks of age.

  • d P < 0.001.

  • e P < 0.01.

  • f P < 0.05.