TABLE 2.

Rapamycin affects some known starvation-sensitive genesa

Gene nameFunctionRapamycin treatment reactionStarvation treatment reactionReference
BCKAD E1-αAmino acid catabolism9
Mitochondrial HMG-CoA synthaseAmino acid catabolism7
VLACDFatty acid oxidation39
Carnitine acetyltransferaseFatty acid oxidationData not shown
UCP2Respiratory chain35
Adenosine deaminaseNucleotide salvageData not shown
Interleukin-4 receptorImmune modulation39
SREBP-1Fatty acid synthesis18
Fatty acid synthaseFatty acid synthesis38
Stearoyl-CoA desaturaseFatty acid synthesis38
Isopentenyl pyrophosphate isomeraseCholesterol synthesisData not shown
Squalene epoxidaseCholesterol synthesisData not shown
Threonyl-tRNA synthetaseProtein synthesis22
eIF2 αProtein synthesis22
  • a Arrows pointed upward indicate up-regulation; those pointed downward indicate down-regulation.