TABLE 1.

TIF2−/− fertility in continous matingsa

GenderGenotypeNo. of mice testedMean no. of pups/litter ± SDMean no. of litters/mouse
FemaleWT46.7 ± 1.03.5 ± 0.3
TIF2+/−116.1 ± 0.43.6 ± 0.3
TIF2−/−62.5 ± 0.3b1.8 ± 0.5b
MaleWT67.8 ± 0.43.5 ± 0.2
TIF2+/−106.8 ± 0.63.4 ± 0.3
TIF2−/−64.6 ± 0.7b2.2 ± 0.7
  • a TIF2 mutant female and male fertility in continuous matings. Control (WT, TIF2+/−) and TIF2−/− females (7 to 10 weeks old) or males were bred with males and females, respectively, for 4 months. The number of 3-week-old pups per litter and the number of litter per female were scored.

  • b Level of significance for the observed differences between WT and TIF2−/− mice, P < 0.05.