TABLE 1

Multivariate Pearson correlation between sgRNA features and gene-normalized sgRNA depletion score

sgRNA featureP value
Overlapping domain0.0018
Relative conservation1.33e−6
Relative burial3.23e−6
Overlapping α-helix8.27e−5
Overlapping β-strand8.33e−6
Overlapping PPI interface0.0034
Overlapping protein disorder3.30e−5