TABLE 2.

Summary of HIF-1α and HIF-2α target genes analyzed in this study

Gene typeProteins
HIF-1α uniqueHexokinase 2, glucosephosphate isomerase, phosphofructokinase, aldoase A, aldolase C, triosephosphate isomerase, glyceraldehyde-3-phosphate dehydrogenase, PGK-1, PGM-1, enolase 1, LDHA
HIF-1α and HIF-2α commonaGlucose transporter 1, ADRP, NDRG-1, DMXL-1, IL-6, Carbonic anhydrase XII, filaggrin, ADM, VEGF
  • a No genes uniquely regulated by HIF-2α have as yet been identified.