TABLE 1.

Genes induced in triplicate sets of hypoxic mRNAs as determined by DNA microarray assaya

GeneACDescriptionAvg fold inductionConfirmation
ADRPX97324Adipose differentiation-related protein2.1Y
NDRG-1D87953N-myc downstream regulated-12.3Y
APG5LY11588APG5 (autophagy 5, S. cerevisiae)-like1.8ND
DMXL-1AJ005821Dmx-like 12.4Y
GRO-2M36820GRO2 oncogene2.3ND
CSTD88667Cerebroside (3′-phosphoadenylylsulfate:galactosylceramide 3′) sulfotransferase1.6ND
NFIL-3X64318Nuclear factor, interleukin 3 regulated1.5ND
AKAP-12U81607A kinase (PRKA) anchor protein (gravin) 121.6ND
POU5F-1Z11898POU domain, class 5, transcription factor 11.4ND
BIRC-3U45878Baculoviral IAP repeat-containing 31.8ND
AA142964ESTs, weakly similar to ORF YOR126c [S. cerevisiae]1.4ND
KIAA0203D86958KIAA0203 gene product1.9ND
PIK3CAZ29090Phosphoinositide-3-kinase, catalytic, alpha polypeptide1.9Y
DUSP-7A1655015Dual-specificity phosphatase 72.1ND
TPP-2M73047Tripeptidyl peptidase II2.1ND
SLC16A4U59185Solute carrier family 16 (monocarboxylic acid transporters), member 43.1ND
KIAA0710AB014610KIAA0710 gene product3.1ND
NDUFB6A1302176NADH dehydrogenase (ubiquinone) 1 beta subcomplex 6 (17 kDa, B17)2.4ND
GADD45AM60974Growth arrest and DNA-damage-inducible, alpha1.5Y
GADD153BC003637Similar to DNA-damage-inducible transcript 31.7Y
IGFBP-3M35878Insulin-like growth factor binding protein 31.5ND
UNGY09008Uracil-DNA glycosylase1.7ND
VEGFAF024710Vascular endothelial growth factor1.4Y
IL-6X04430Interleukin 6 (interferon, beta 2)2.0Y
CA-12AF037335Carbonic anhydrase XII2.2Y
FLGM60502Filaggrin1.5Y
CCND-1X59798Cyclin D1 (PRAD1: parathyroid adenomatosis 1)1.8Y
SLC2A1K03195Solute carrier family 2, member 12.0Y
ADMD14874Adrenomedullin2.3Y
  • a The threshold indicative of an induced gene was set at 1.4-fold since Affymetrix DNA chips appeared to underestimate the differences between the values of the control and the experimental samples. AC, GenBank accession number; Y, hypoxic induction confirmed by Northern blot assay; ND, not determined.