TABLE 1.

Levels in pancreatic tissue of Rab3D and proteins involved in membrane traffica

Protein% (Range) of protein in mouse type:
+/+−/−
Synaptobrevin 2100 (96.3-103.4)97.9 (92.9-105.2)
SNAP-23100 (95.9-105.4)120.1 (117.8-124.1)
Cellubrevin100 (92.4-111.6)92.2 (82.1-103.6)
Endobrevin100 (94.1-104.4)97.9 (95.4-99.5)
Syntaxin 7100 (91.6-111.1)102.2 (78.8-117.4)
Syntaxin 13100 (90.1-117.2)102.4 (90.1-112.7)
Syntaxin 8100 (91.8-110.9)106.8 (98.2-112.3)
Syntaxin 6100 (85.3-109.6)91.6 (81.5-98.2)
Syntaxin 2100 (93.2-105.3)99.3 (94.5-105.6)
Syntaxin 3100 (98.3-102.9)97.3 (90.9-102.9)
Syntaxin 4100 (92.7-104.1)94.1 (89.4-100.9)
SCAMP100 (93.4-105.8)102.3 (98.4-105.9)
Syncollin100 (93.3-103.4)98.5 (90.7-109.5)
NSF100 (94.6-105.5)95.5 (89.0-100.0)
GDI100 (95.7-107.6)97.9 (95.6-102.1)
β-Tubulin100 (94.4-106.8)98.5 (87.8-106.7)
Rabphilin100 (94.2-107.2)97.6 (89.6-105.1)
Rab3D100 (95.5-105.8)3.9 (1.4-7.9)
  • a Pancreatic proteins derived from wild-type (+/+) and KO (−/−) mice (three mice per group) were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and quantitative immunoblotting. Signals were normalized to the signal average of wild-type mice and are given as percentages.