TABLE 2.

Echocardiographic measurements in calcineurin-transgenic mice crossed into the NFATc3-null background at 10 weeks of agea

ParameterMean ± SEM in:
NFATc3+/+ mice (n = 5)NFATc3−/− mice (n = 9)CnTG NFATc3+/+ mice (n = 10)CnTG NFATc3−/− mice (n = 7)
Septum (mm)0.68 ± 0.050.66 ± 0.040.79 ± 0.04∗0.68 ± 0.04∗∗
LV free wall (mm)0.59 ± 0.050.62 ± 0.040.71 ± 0.04∗0.56 ± 0.05∗∗
LVEDD (mm)3.68 ± 0.123.42 ± 0.124.41 ± 0.24∗3.83 ± 0.28∗∗
LVESD (mm)2.34 ± 0.142.13 ± 0.123.30 ± 0.17∗2.95 ± 0.20∗∗
FS (%)36.5 ± 2.637.6 ± 2.524.7 ± 2.2∗22.5 ± 2.5∗
  • a NFATc3 wild-type mice and NFATc3-null mice were compared at baseline or when crossed into the calcineurin-transgenic background by echocardiography. Each mouse was measured three times (5 to 10 mice in each group). LV, left ventricle measured in diastole; LVEDD, left ventricular end-diastolic dimension; LVESD, left ventricular end-systolic dimension. Fractional shortening (FS) was calculated as (LVEDD − LVESD)/LVEDD × 100. ∗, P < 0.05 versus NFATc3+/+ mice; ∗∗, P < 0.05 versus CnTG NFATc3+/+ mice. n = number of mice.