TABLE 1.

Association of prolonged G2 accumulation with defective S-phase checkpointa

Cell line and transfectionS-phase checkpointEarly G2/M checkpointG2 accumulationRadiation sensitivity
NBS1-LBI
Vector+Prolonged
Wild-type Nbs1++++
S343A Nbs1+Prolonged+
HCC1937
VectorProlonged
Wild-type Brca1++++
S1423A Brca1+++
  • a −, abnormal; +, normal; ↑, hypersensitive.