TABLE 1.

Oligopyrimidine sequences at the 5′ and 3′ frameshift variable regions in the LF3 gene and repeat copy numbers from different sourcesa

EBV strain (repeat copy no.)5′-end sequence3′-end sequencePattern
C15∗ (22.7)CCCCCCCCCCCC1
C17∗ (27.7)CCCCCCCCCCC2
C18∗ (24.7)CCCCCCCCCCCC1
NPC 1∗∗ (23.7)TCCCCCCCCCC3
NPC 2∗∗ (22.7)TCCCCCCCCCC3
M-ABA (25.7)TCCCCCCCC6
Raji (24.7)TCCCCCCCCC4
Daudi-ICRF/ATCC (23.7)TCCCCCCCCCC3
Daudi 100K (ND)TCCCCCCCCCC3
P3HR-1 (21.7, 25.7)CCCCCCCCCCCC1
BL-74 (25.7)TCCCCCCCCCC3
BL-001+ (28.7)TCCCCCCCCC4
BL-002+ (24.7)TCCCCCCCCC4
BL-003+ (24.7)TCCCCCCCCC4
BL-004+ (24.7)TCCCCCCCCC4
BL-005+ (29.7)TCCCCCCCCC4
BL-006+ (33.7)TCCCCCCCCCC3
BL-007+ (29.7)TCCCCCCCCC4
BL-SD+ (28.7)TCCCCCCCCC4
BL-IB+ (23.7)TCCCCCCCCC4
M81 (ND)TCCCCCCCCCC3
  • a All cells except M81, a marmoset line, were from human sources. ND, not done. ∗, xenografts from North African NPCs. ∗∗, Chinese NPC biopsies. ≠, cell lines from African Burkitt's lymphomas (BLs). +, BL biopsies. Combinations of sequences are designated, respectively: 5′-C6 with 3′-C6 or C5, 1 and 2; 5′ TC4 with 3′-C6 or C5, 3 and 4; 5′-TC3 with 3′-C6 or C5, 5 and 6. Only combination patterns 1 and 6 with nucleotide numbers (n = 12 or 9) divisible by 3 are predicted to have initiation and termination codons in the same reading frames in their transcripts and thus accommodate a protein (see Fig. 2).