TABLE 1.

PDX-ATF3 mice have low body weight and defects secondary to β-cell deficiencya

Mouse groupMean body wt ± SE (g)Mean blood glucose level ± SE (mg/dl)Mean level in serum ± SE
Insulin (ng/dl)Glucagon (pg/ml)TG (mg/dl)β-OH-buty (mg/dl)
Non-Txg1.54 ± 0.1073 ± 34.3 ± 1.1180 ± 21125 ± 119.6 ± 0.8
Txg1.26 ± 0.08347 ± 35b<0.2b231 ± 61194 ± 8b16.6 ± 1.9b
  • a Non-transgenic (Non-Txg) or transgenic (Txg) mice at postnatal day 1 to 3 were sacrificed. Body weight, blood glucose level, and levels of insulin, glucagon, triglyceride (TG), or β-hydroxybutyrate (β-OH-buty.) were analyzed. Data represent are based on four samples, with each sample containing combined sera from three to four mice.

  • b P < 0.001 for comparison with values for non-Txg mice.