γ-glutamyl carboxylase

  • Vitamin K-Dependent γ-Glutamyl Carboxylase in Sertoli Cells Is Essential for Male Fertility in Mice
    Research Article | Spotlight
    Vitamin K-Dependent γ-Glutamyl Carboxylase in Sertoli Cells Is Essential for Male Fertility in Mice

    γ-Glutamyl carboxylase (GGCX) is a vitamin K (VK)-dependent enzyme that catalyzes the γ-carboxylation of glutamic acid residues in VK-dependent proteins. The anticoagulant warfarin is known to reduce GGCX activity by inhibiting the VK cycle and was recently shown to disrupt spermatogenesis.

    Sachiko Shiba, Kazuhiro Ikeda, Kuniko Horie-Inoue, Kotaro Azuma, Tomoka Hasegawa, Norio Amizuka, Tomoaki Tanaka, Toshihiko Takeiwa, Yasuaki Shibata, Takehiko Koji, Satoshi Inoue
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