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adipocytes

  • Unraveling the Hierarchy of <em>cis</em> and <em>trans</em> Factors That Determine the DNA Binding by Peroxisome Proliferator-Activated Receptor γ
    Research Article | Spotlight
    Unraveling the Hierarchy of cis and trans Factors That Determine the DNA Binding by Peroxisome Proliferator-Activated Receptor γ

    Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor essential for adipocyte development and the maintenance of the alternatively polarized macrophage phenotype. Biochemical studies have established that as an obligate heterodimer with retinoid X receptor (RXR), PPARγ binds directly repeated nuclear receptor half sites spaced by one nucleotide (direct repeat 1 [DR1]). However, it has not been analyzed...

    Gergely Nagy, Bence Daniel, Ixchelt Cuaranta-Monroy, Laszlo Nagy
  • During Adipocyte Remodeling, Lipid Droplet Configurations Regulate Insulin Sensitivity through F-Actin and G-Actin Reorganization
    Research Article | Spotlight
    During Adipocyte Remodeling, Lipid Droplet Configurations Regulate Insulin Sensitivity through F-Actin and G-Actin Reorganization

    Adipocytes have unique morphological traits in insulin sensitivity control. However, how the appearance of adipocytes can determine insulin sensitivity has not been understood. Here, we demonstrate that actin cytoskeleton reorganization upon lipid droplet (LD) configurations in adipocytes plays important roles in insulin-dependent glucose uptake by regulating GLUT4 trafficking.

    Jong In Kim, Jeu Park, Yul Ji, Kyuri Jo, Sang Mun Han, Jee Hyung Sohn, Kyung Cheul Shin, Ji Seul Han, Yong Geun Jeon, Hahn Nahmgoong, Kyung Hee Han, Jiwon Kim, Sun Kim, Sung Sik Choe, Jae Bum Kim
  • Interleukin-8 Activates Breast Cancer-Associated Adipocytes and Promotes Their Angiogenesis- and Tumorigenesis-Promoting Effects
    Research Article
    Interleukin-8 Activates Breast Cancer-Associated Adipocytes and Promotes Their Angiogenesis- and Tumorigenesis-Promoting Effects

    Increasing evidence supports the critical role of active stromal adipocytes in breast cancer development and spread. However, the mediators and the mechanisms of action are still elusive.

    Huda H. Al-Khalaf, Bothaina Al-Harbi, Adher Al-Sayed, Maria Arafah, Asma Tulbah, Abdulaziz Jarman, Falah Al-Mohanna, Abdelilah Aboussekhra
  • Research Article
    Obesity and p16INK4A Downregulation Activate Breast Adipocytes and Promote Their Protumorigenicity
    Huda H. Al-Khalaf, Mrad Amir, Falah Al-Mohanna, Asma Tulbah, Adher Al-Sayed, Abdelilah Aboussekhra
  • Articles
    Insulin Regulates Adipocyte Lipolysis via an Akt-Independent Signaling Pathway
    Sarah M. Choi, David F. Tucker, Danielle N. Gross, Rachael M. Easton, Lisa M. DiPilato, Abigail S. Dean, Bob R. Monks, Morris J. Birnbaum
  • Articles
    Epidermis-Type Lipoxygenase 3 Regulates Adipocyte Differentiation and Peroxisome Proliferator-Activated Receptor γ Activity
    Philip Hallenborg, Claus Jørgensen, Rasmus K. Petersen, Søren Feddersen, Pedro Araujo, Patrick Markt, Thierry Langer, Gerhard Furstenberger, Peter Krieg, Arjen Koppen, Eric Kalkhoven, Lise Madsen, Karsten Kristiansen
  • Articles
    Pref-1 Interacts with Fibronectin To Inhibit Adipocyte Differentiation
    Yuhui Wang, Ling Zhao, Cynthia Smas, Hei Sook Sul
  • Articles
    Lipin 1 Represses NFATc4 Transcriptional Activity in Adipocytes To Inhibit Secretion of Inflammatory Factors
    Hyun Bae Kim, Anil Kumar, Lifu Wang, Guang-Hui Liu, Susanna R. Keller, John C. Lawrence, Brian N. Finck, Thurl E. Harris
  • Free
    Articles
    Cell-Specific Determinants of Peroxisome Proliferator-Activated Receptor γ Function in Adipocytes and Macrophages
    Martina I. Lefterova, David J. Steger, David Zhuo, Mohammed Qatanani, Shannon E. Mullican, Geetu Tuteja, Elisabetta Manduchi, Gregory R. Grant, Mitchell A. Lazar
  • Free
    Commentary
    Peroxisome Proliferator-Activated Receptor γ Dances with Different Partners in Macrophage and Adipocytes
    Elena Scotti, Peter Tontonoz

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