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alternative splicing

  • Multilevel Regulation of Protein Kinase CδI Alternative Splicing by Lithium Chloride
    Research Article
    Multilevel Regulation of Protein Kinase CδI Alternative Splicing by Lithium Chloride

    Lithium chloride (LiCl) is commonly used in treatment of mood disorders; however, its usage leads to weight gain, which promotes metabolic disorders. Protein kinase C delta (PKCδ), a serine/threonine kinase, is alternatively spliced to PKCδI and PKCδII in 3T3-L1 cells.

    Deena Bader, Rekha S. Patel, Ashley Lui, Chetna Thawani, Rea Rupani, Gitanjali Vidyarthi, Niketa A. Patel
  • Alternative Splicing and Cleavage of GLUT8
    Research Article
    Alternative Splicing and Cleavage of GLUT8

    The GLUT (SLC2) family of membrane-associated transporters are described as glucose transporters. However, this family is divided into three classes and, though the regulated transporter activity of class I proteins is becoming better understood, class III protein functions continue to be obscure. We have cataloged the relative expression and splicing of SLC2 mRNA isomers in tumors and normal tissues, with a focus on...

    Caroline M. Alexander, Joshua A. Martin, Elias Oxman, Ildiko Kasza, Katherine A. Senn, Heidi Dvinge
  • Open Access
    TIN2 Functions with TPP1/POT1 To Stimulate Telomerase Processivity
    Research Article | Spotlight
    TIN2 Functions with TPP1/POT1 To Stimulate Telomerase Processivity

    TIN2 is an important regulator of telomere length, and mutations in TINF2, the gene encoding TIN2, cause short-telomere syndromes. While the genetics underscore the importance of TIN2, the mechanism through which TIN2 regulates telomere length remains unclear. Here, we tested the effects of human TIN2 on telomerase activity. We identified a new isoform in human cells, TIN2M, that is expressed at levels similar to those of...

    Alexandra M. Pike, Margaret A. Strong, John Paul T. Ouyang, Carol W. Greider
  • Research Article
    Poly(C)-Binding Protein Pcbp2 Enables Differentiation of Definitive Erythropoiesis by Directing Functional Splicing of the Runx1 Transcript

    Formation of the mammalian hematopoietic system is under a complex set of developmental controls. Here, we report that mouse embryos lacking the KH domain poly(C) binding protein, Pcbp2, are selectively deficient in the definitive erythroid lineage.

    Louis R. Ghanem, Andrew Kromer, Ian M. Silverman, Xinjun Ji, Matthew Gazzara, Nhu Nguyen, Gabrielle Aguilar, Massimo Martinelli, Yoseph Barash, Stephen A. Liebhaber
  • Open Access
    Research Article
    Multilevel Differential Control of Hormone Gene Expression Programs by hnRNP L and LL in Pituitary Cells
    Lei Lei, Wenguang Cao, Ling Liu, Urmi Das, Yujia Wu, Guodong Liu, Muhammad Sohail, Yangjun Chen, Jiuyong Xie
  • Research Article
    RBM4 Modulates Radial Migration via Alternative Splicing of Dab1 during Cortex Development
    Dhananjaya D, Kuan-Yang Hung, Woan-Yuh Tarn
  • Research Article
    A High-Resolution Genome-Wide CRISPR/Cas9 Viability Screen Reveals Structural Features and Contextual Diversity of the Human Cell-Essential Proteome
    Thierry Bertomeu, Jasmin Coulombe-Huntington, Andrew Chatr-aryamontri, Karine G. Bourdages, Etienne Coyaud, Brian Raught, Yu Xia, Mike Tyers
  • Research Article
    Protein 4.1R Exon 16 3′ Splice Site Activation Requires Coordination among TIA1, Pcbp1, and RBM39 during Terminal Erythropoiesis
    Shu-Ching Huang, Henry S. Zhang, Brian Yu, Ellen McMahon, Dan T. Nguyen, Faye H. Yu, Alexander C. Ou, Jennie Park Ou, Edward J. Benz
  • Research Article
    Activation-Dependent TRAF3 Exon 8 Alternative Splicing Is Controlled by CELF2 and hnRNP C Binding to an Upstream Intronic Element
    Astrid-Solveig Schultz, Marco Preussner, Mario Bunse, Rotem Karni, Florian Heyd
  • Research Article
    RBM4 Regulates Neuronal Differentiation of Mesenchymal Stem Cells by Modulating Alternative Splicing of Pyruvate Kinase M
    Chun-Hao Su, Kuan-Yang Hung, Shih-Chieh Hung, Woan-Yuh Tarn

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