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brain

  • Determining the Bioenergetic Capacity for Fatty Acid Oxidation in the Mammalian Nervous System
    Research Article | Spotlight
    Determining the Bioenergetic Capacity for Fatty Acid Oxidation in the Mammalian Nervous System

    The metabolic state of the brain can greatly impact neurologic function. Evidence of this includes the therapeutic benefit of a ketogenic diet in neurologic diseases, including epilepsy. However, brain lipid bioenergetics remain largely uncharacterized. The existence, capacity, and relevance of mitochondrial fatty acid β-oxidation (FAO) in the brain are highly controversial, with few genetic tools available to evaluate the question. We...

    Cory J. White, Jieun Lee, Joseph Choi, Tiffany Chu, Susanna Scafidi, Michael J. Wolfgang
  • Research Article
    Mice Deficient in lysophosphatidic acid acyltransferase delta (Lpaatδ)/acylglycerophosphate acyltransferase 4 (Agpat4) Have Impaired Learning and Memory
    Ryan M. Bradley, Emily B. Mardian, Darin Bloemberg, Juan J. Aristizabal Henao, Andrew S. Mitchell, Phillip M. Marvyn, Katherine A. Moes, Ken D. Stark, Joe Quadrilatero, Robin E. Duncan
  • Research Article | Spotlight
    FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem Progenitor Cells
    Takayoshi Yamauchi, Masaaki Nishiyama, Toshiro Moroishi, Atsuki Kawamura, Keiichi I. Nakayama
  • Articles
    Dual Functions of Dab1 during Brain Development
    Libing Feng, Jonathan A. Cooper
  • Articles
    Barhl1 Regulatory Sequences Required for Cell-Specific Gene Expression and Autoregulation in the Inner Ear and Central Nervous System
    Ramesh Chellappa, Shengguo Li, Sarah Pauley, Israt Jahan, Kangxin Jin, Mengqing Xiang
  • Articles
    Targeted Deletion of the Mitogen-Activated Protein Kinase Kinase 4 Gene in the Nervous System Causes Severe Brain Developmental Defects and Premature Death
    Xin Wang, Bagirathy Nadarajah, Andrew C. Robinson, Barry W. McColl, Jia-Wei Jin, Federico Dajas-Bailador, Raymond P. Boot-Handford, Cathy Tournier
  • Articles
    Deletion of Shp2 in the Brain Leads to Defective Proliferation and Differentiation in Neural Stem Cells and Early Postnatal Lethality
    Yuehai Ke, Eric E. Zhang, Kazuki Hagihara, Dongmei Wu, Yuhong Pang, Rüdiger Klein, Tom Curran, Barbara Ranscht, Gen-Sheng Feng
  • Articles
    A Brain-Specific Homeobox Gene, Bsx, Is Essential for Proper Postnatal Growth and Nursing
    Tara McArthur, Akihira Ohtoshi
  • Articles
    Nuclear Factor I X Deficiency Causes Brain Malformation and Severe Skeletal Defects
    Katrin Driller, Axel Pagenstecher, Markus Uhl, Heymut Omran, Ansgar Berlis, Albert Gründer, Albrecht E. Sippel
  • Articles
    Ca2+/Calmodulin Kinase Kinase α Is Dispensable for Brain Development but Is Required for Distinct Memories in Male, though Not in Female, Mice
    Keiko Mizuno, Laurence Ris, Amelia Sánchez-Capelo, Emile Godaux, K. Peter Giese

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