cancer
CommentaryBugs as Cancer Drugs: Challenges and OpportunitiesThe first nonsurgical cancer therapy was bacterial therapy introduced in 1891 to treat solid tumors. Because in many cases it was harmful and ineffective, and with the emergence of radiotherapy and chemotherapy, bacterial therapy was discontinued.
Research Article | SpotlightUncoupling the Senescence-Associated Secretory Phenotype from Cell Cycle Exit via Interleukin-1 Inactivation Unveils Its Protumorigenic RoleCellular senescence has emerged as a potent tumor suppressor mechanism in numerous human neoplasias. Senescent cells secrete a distinct set of factors, collectively termed the senescence-associated secretory phenotype (SASP), which has been postulated to carry both pro- and antitumorigenic properties depending on tissue context.
- Research Article | SpotlightId2 Determines Intestinal Identity through Repression of the Foregut Transcription Factor Irx5
- Research Article | SpotlightEvidence of a Prion-Like Transmission of p53 Amyloid in Saccharomyces cerevisiae