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cell proliferation

  • EHD1 and RUSC2 Control Basal Epidermal Growth Factor Receptor Cell Surface Expression and Recycling
    Research Article
    EHD1 and RUSC2 Control Basal Epidermal Growth Factor Receptor Cell Surface Expression and Recycling

    Epidermal growth factor receptor (EGFR) is a prototype receptor tyrosine kinase and an oncoprotein in many solid tumors. Cell surface display of EGFR is essential for cellular responses to its ligands. While postactivation endocytic trafficking of EGFR has been well elucidated, little is known about mechanisms of basal/preactivation surface display of EGFR. Here, we identify a novel role of the endocytic regulator EHD1 and a potential...

    Eric C. Tom, Insha Mushtaq, Bhopal C. Mohapatra, Haitao Luan, Aaqib M. Bhat, Neha Zutshi, Sukanya Chakraborty, Namista Islam, Priyanka Arya, Timothy A. Bielecki, Fany M. Iseka, Sohinee Bhattacharyya, Luke R. Cypher, Benjamin T. Goetz, Simarjeet K. Negi, Matthew D. Storck, Sandeep Rana, Angelika Barnekow, Pankaj K. Singh, Guoguang Ying, Chittibabu Guda, Amarnath Natarajan, Vimla Band, Hamid Band
  • Long Noncoding RNA H19 Promotes Tumorigenesis of Multiple Myeloma by Activating BRD4 Signaling by Targeting MicroRNA 152-3p
    Research Article
    Long Noncoding RNA H19 Promotes Tumorigenesis of Multiple Myeloma by Activating BRD4 Signaling by Targeting MicroRNA 152-3p

    Multiple myeloma (MM) accounts for over twenty percent of hematological cancer-related death worldwide. Long noncoding RNA (lncRNA) H19 is associated with multiple tumorigenesis and is increased in MM, but the underlying mechanism of H19 in MM is unclear. In this study, the expression of H19, microRNA 152-3p (miR-152-3p), and BRD4 in MM patients was evaluated by quantitative real-time PCR (qRT-PCR) and Western blotting.

    ...
    Ji-Fu Zheng, Ning-Hong Guo, Fu-Ming Zi, Jing Cheng
  • A Novel Regulatory Axis, CHD1L-MicroRNA 486-Matrix Metalloproteinase 2, Controls Spermatogonial Stem Cell Properties
    Research Article
    A Novel Regulatory Axis, CHD1L-MicroRNA 486-Matrix Metalloproteinase 2, Controls Spermatogonial Stem Cell Properties

    Spermatogonial stem cells (SSCs) are unipotent germ cells that are at the foundation of spermatogenesis and male fertility. However, the underlying molecular mechanisms governing SSC stemness and growth properties remain elusive.

    Shan-Shan Liu, Eithne Margaret Maguire, Yin-Shan Bai, Li Huang, Yurong Liu, Liping Xu, Iliana Fauzi, Shou-Quan Zhang, Qingzhong Xiao, Ning-Fang Ma
  • Research Article | Spotlight
    Neutrophil and Macrophage Cell Surface Colony-Stimulating Factor 1 Shed by ADAM17 Drives Mouse Macrophage Proliferation in Acute and Chronic Inflammation

    Macrophages are prominent cells in acute and chronic inflammatory diseases. Recent studies highlight a role for macrophage proliferation post-monocyte recruitment under inflammatory conditions.

    Jingjing Tang, Jeremy M. Frey, Carole L. Wilson, Angela Moncada-Pazos, Clémence Levet, Matthew Freeman, Michael E. Rosenfeld, E. Richard Stanley, Elaine W. Raines, Karin E. Bornfeldt
  • Research Article | Spotlight
    EYA1's Conformation Specificity in Dephosphorylating Phosphothreonine in Myc and Its Activity on Myc Stabilization in Breast Cancer
    Jun Li, Yoel Rodriguez, Chunming Cheng, Lei Zeng, Elaine Y. M. Wong, Chelsea Y. Xu, Ming-Ming Zhou, Pin-Xian Xu
  • Articles
    Las1L Is a Nucleolar Protein Required for Cell Proliferation and Ribosome Biogenesis
    Christopher D. Castle, Erica K. Cassimere, Jinho Lee, Catherine Denicourt
  • Articles | Spotlight
    Ikaros and Aiolos Inhibit Pre-B-Cell Proliferation by Directly Suppressing c-Myc Expression
    Shibin Ma, Simanta Pathak, Malay Mandal, Long Trinh, Marcus R. Clark, Runqing Lu
  • Articles
    NADPH Oxidase 1 Modulates WNT and NOTCH1 Signaling To Control the Fate of Proliferative Progenitor Cells in the Colon
    Nicolas Coant, Sanae Ben Mkaddem, Eric Pedruzzi, Cécile Guichard, Xavier Tréton, Robert Ducroc, Jean-Noel Freund, Dominique Cazals-Hatem, Yoram Bouhnik, Paul-Louis Woerther, David Skurnik, Alain Grodet, Michèle Fay, Denis Biard, Thécla Lesuffleur, Christine Deffert, Richard Moreau, André Groyer, Karl-Heinz Krause, Fanny Daniel, Eric Ogier-Denis
  • Articles
    Disruption of CK2β in Embryonic Neural Stem Cells Compromises Proliferation and Oligodendrogenesis in the Mouse Telencephalon
    Emmanuelle Huillard, Léa Ziercher, Olivier Blond, Michael Wong, Jean-Christophe Deloulme, Serhiy Souchelnytskyi, Jacques Baudier, Claude Cochet, Thierry Buchou
  • Articles
    Targeted Deletion of Capn4 in Cells of the Chondrocyte Lineage Impairs Chondrocyte Proliferation and Differentiation
    Aki Kashiwagi, Ernestina Schipani, Mikaela J. Fein, Peter A. Greer, Masako Shimada

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