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cell signaling

  • A Fresh Look at the Structure, Regulation, and Functions of Fodrin
    Minireview
    A Fresh Look at the Structure, Regulation, and Functions of Fodrin

    Fodrin and its erythroid cell-specific isoform spectrin are actin-associated fibrous proteins that play crucial roles in the maintenance of structural integrity in mammalian cells, which is necessary for proper cell function. Normal cell morphology is altered in diseases such as various cancers and certain neuronal disorders. Fodrin and spectrin are two-chain (αβ) molecules that are encoded by paralogous genes and share many features...

    Jamuna S. Sreeja, Rince John, Dhrishya Dharmapal, Rohith Kumar Nellikka, Suparna Sengupta
  • Open Access
    RACK1 Specifically Regulates Translation through Its Binding to Ribosomes
    Research Article | Spotlight
    RACK1 Specifically Regulates Translation through Its Binding to Ribosomes

    The translational capability of ribosomes deprived of specific nonfundamental ribosomal proteins may be altered. Physiological mechanisms are scanty, and it is unclear whether free ribosomal proteins can cross talk with the signaling machinery.

    Simone Gallo, Sara Ricciardi, Nicola Manfrini, Elisa Pesce, Stefania Oliveto, Piera Calamita, Marilena Mancino, Elisa Maffioli, Monica Moro, Mariacristina Crosti, Valeria Berno, Mauro Bombaci, Gabriella Tedeschi, Stefano Biffo
  • Research Article
    Endothelial NO Synthase-Dependent S-Nitrosylation of β-Catenin Prevents Its Association with TCF4 and Inhibits Proliferation of Endothelial Cells Stimulated by Wnt3a
    Ying Zhang, Rony Chidiac, Chantal Delisle, Jean-Philippe Gratton
  • Research Article
    Phosphorylated Nuclear Receptor CAR Forms a Homodimer To Repress Its Constitutive Activity for Ligand Activation
    Ryota Shizu, Makoto Osabe, Lalith Perera, Rick Moore, Tatsuya Sueyoshi, Masahiko Negishi
  • Open Access
    Research Article
    A Two-Tiered Mechanism Enables Localized Cdc42 Signaling during Enterocyte Polarization
    Lucas J. M. Bruurs, Susan Zwakenberg, Mirjam C. van der Net, Fried J. Zwartkruis, Johannes L. Bos
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