circular RNA

  • A Circular RNA from the <em>MDM2</em> Locus Controls Cell Cycle Progression by Suppressing p53 Levels
    Research Article | Spotlight
    A Circular RNA from the MDM2 Locus Controls Cell Cycle Progression by Suppressing p53 Levels

    Circular RNAs (circRNAs) are a class of noncoding RNAs produced by a noncanonical form of alternative splicing called back-splicing. To investigate a potential role of circRNAs in the p53 pathway, we analyzed RNA sequencing (RNA-seq) data from colorectal cancer cell lines (HCT116, RKO, and SW48) that were untreated or treated with a DNA-damaging agent. Surprisingly, unlike the strong p53-dependent induction of hundreds of p53-induced...

    Ritu Chaudhary, Bruna R. Muys, Ioannis Grammatikakis, Supriyo De, Kotb Abdelmohsen, Xiao Ling Li, Yuelin Zhu, Swapna Vidhur Daulatabad, Dimitrios Tsitsipatis, Paul S. Meltzer, Myriam Gorospe, Sarath Chandra Janga, Ashish Lal
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