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CpG Islands

  • DHX33 Recruits Gadd45a To Cause DNA Demethylation and Regulates a Subset of Gene Transcription
    Research Article
    DHX33 Recruits Gadd45a To Cause DNA Demethylation and Regulates a Subset of Gene Transcription

    RNA helicase DHX33 was found to regulate the transcription of multiple genes involved in cancer development. But the underlying molecular mechanism remains unclear. Here, we found DHX33 associated extensively with gene promoters at CG-rich region. Its deficiency reduced the loading of active RNA polymerase II at gene promoters. Furthermore, we observed a functional interaction between DHX33, AP-2β, and DNA demethylation protein Gadd45a...

    Weimin Feng, Shiyun Chen, Jiuling Wang, Xingshun Wang, Huaiyong Chen, Wen Ning, Yandong Zhang
  • Articles
    Selective Anchoring of DNA Methyltransferases 3A and 3B to Nucleosomes Containing Methylated DNA
    Shinwu Jeong, Gangning Liang, Shikhar Sharma, Joy C. Lin, Si Ho Choi, Han Han, Christine B. Yoo, Gerda Egger, Allen S. Yang, Peter A. Jones
  • Articles
    SALL3 Interacts with DNMT3A and Shows the Ability To Inhibit CpG Island Methylation in Hepatocellular Carcinoma
    Yuko Shikauchi, Akio Saiura, Takahiko Kubo, Yasuharu Niwa, Junji Yamamoto, Yaeko Murase, Hirohide Yoshikawa
  • Articles
    CpG Hypomethylation in a Large Domain Encompassing the Embryonic β-Like Globin Genes in Primitive Erythrocytes
    Mei Hsu, Rodwell Mabaera, Christopher H. Lowrey, David I. K. Martin, Steven Fiering
  • Articles
    Differential Recruitment of Methylated CpG Binding Domains by the Orphan Receptor GCNF Initiates the Repression and Silencing of Oct4 Expression
    Peili Gu, Damien Le Menuet, Arthur C.-K. Chung, Austin J. Cooney
  • Articles
    Specific Differentially Methylated Domain Sequences Direct the Maintenance of Methylation at Imprinted Genes
    Bonnie Reinhart, Ariane Paoloni-Giacobino, J. Richard Chaillet
  • GENE EXPRESSION
    A Novel Variant of Inpp5f Is Imprinted in Brain, and Its Expression Is Correlated with Differential Methylation of an Internal CpG Island
    Jonathan D. Choi, Lara A. Underkoffler, Andrew J. Wood, Joelle N. Collins, Patrick T. Williams, Jeffrey A. Golden, Eugene F. Schuster, Kathleen M. Loomes, Rebecca J. Oakey
  • CHROMOSOME STRUCTURE AND DYNAMICS
    Reduced Genomic Cytosine Methylation and Defective Cellular Differentiation in Embryonic Stem Cells Lacking CpG Binding Protein
    Diana L. Carlone, Jeong-Heon Lee, Suzanne R. L. Young, Erika Dobrota, Jill Sergesketter Butler, Joseph Ruiz, David G. Skalnik
  • CELL GROWTH AND DEVELOPMENT
    Binding to Nonmethylated CpG DNA Is Essential for Target Recognition, Transactivation, and Myeloid Transformation by an MLL Oncoprotein
    Paul M. Ayton, Everett H. Chen, Michael L. Cleary
  • GENE EXPRESSION
    Enhancement of Sleeping Beauty Transposition by CpG Methylation: Possible Role of Heterochromatin Formation
    Kosuke Yusa, Junji Takeda, Kyoji Horie

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