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cytoskeleton

  • A Fresh Look at the Structure, Regulation, and Functions of Fodrin
    Minireview
    A Fresh Look at the Structure, Regulation, and Functions of Fodrin

    Fodrin and its erythroid cell-specific isoform spectrin are actin-associated fibrous proteins that play crucial roles in the maintenance of structural integrity in mammalian cells, which is necessary for proper cell function. Normal cell morphology is altered in diseases such as various cancers and certain neuronal disorders. Fodrin and spectrin are two-chain (αβ) molecules that are encoded by paralogous genes and share many features...

    Jamuna S. Sreeja, Rince John, Dhrishya Dharmapal, Rohith Kumar Nellikka, Suparna Sengupta
  • During Adipocyte Remodeling, Lipid Droplet Configurations Regulate Insulin Sensitivity through F-Actin and G-Actin Reorganization
    Research Article | Spotlight
    During Adipocyte Remodeling, Lipid Droplet Configurations Regulate Insulin Sensitivity through F-Actin and G-Actin Reorganization

    Adipocytes have unique morphological traits in insulin sensitivity control. However, how the appearance of adipocytes can determine insulin sensitivity has not been understood. Here, we demonstrate that actin cytoskeleton reorganization upon lipid droplet (LD) configurations in adipocytes plays important roles in insulin-dependent glucose uptake by regulating GLUT4 trafficking.

    Jong In Kim, Jeu Park, Yul Ji, Kyuri Jo, Sang Mun Han, Jee Hyung Sohn, Kyung Cheul Shin, Ji Seul Han, Yong Geun Jeon, Hahn Nahmgoong, Kyung Hee Han, Jiwon Kim, Sun Kim, Sung Sik Choe, Jae Bum Kim
  • Articles
    Cdk5-Dependent Regulation of Rho Activity, Cytoskeletal Contraction, and Epithelial Cell Migration via Suppression of Src and p190RhoGAP
    Brajendra K. Tripathi, Peggy S. Zelenka
  • Articles
    MST Kinases Monitor Actin Cytoskeletal Integrity and Signal via c-Jun N-Terminal Kinase Stress-Activated Kinase To Regulate p21Waf1/Cip1 Stability
    Ruth M. Densham, Eric O'Neill, June Munro, Ireen König, Kurt Anderson, Walter Kolch, Michael F. Olson
  • Articles
    The Yeast AAA+ Chaperone Hsp104 Is Part of a Network That Links the Actin Cytoskeleton with the Inheritance of Damaged Proteins
    Peter Tessarz, Michael Schwarz, Axel Mogk, Bernd Bukau
  • Articles
    The Atypical Rho GTPase Wrch1 Collaborates with the Nonreceptor Tyrosine Kinases Pyk2 and Src in Regulating Cytoskeletal Dynamics
    Aino Ruusala, Pontus Aspenström
  • Articles
    Localization to the Cortical Cytoskeleton Is Necessary for Nf2/Merlin-Dependent Epidermal Growth Factor Receptor Silencing
    Banumathi K. Cole, Marcello Curto, Annie W. Chan, Andrea I. McClatchey
  • Articles
    Calpain 6 Is Involved in Microtubule Stabilization and Cytoskeletal Organization
    Kazuo Tonami, Yukiko Kurihara, Hiroyuki Aburatani, Yasunobu Uchijima, Tomoichiro Asano, Hiroki Kurihara
  • Articles
    Improper Organization of the Actin Cytoskeleton Affects Protein Synthesis at Initiation
    Stephane R. Gross, Terri Goss Kinzy
  • Articles
    SUN1 Interacts with Nuclear Lamin A and Cytoplasmic Nesprins To Provide a Physical Connection between the Nuclear Lamina and the Cytoskeleton
    Farhana Haque, David J. Lloyd, Dawn T. Smallwood, Carolyn L. Dent, Catherine M. Shanahan, Andrew M. Fry, Richard C. Trembath, Sue Shackleton

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