estrogen receptor

  • Genome-Wide Analysis Unveils DNA Helicase RECQ1 as a Regulator of Estrogen Response Pathway in Breast Cancer Cells
    Research Article
    Genome-Wide Analysis Unveils DNA Helicase RECQ1 as a Regulator of Estrogen Response Pathway in Breast Cancer Cells

    Susceptibility to breast cancer is significantly increased in individuals with germ line mutations in RECQ1 (also known as RECQL or RECQL1), a gene encoding a DNA helicase essential for genome maintenance. We previously reported that RECQ1 expression predicts clinical outcomes for sporadic breast cancer patients stratified by estrogen receptor (ER) status.

    Xing Lu, Christophe E. Redon, Wei Tang, Swetha Parvathaneni, Bayan Bokhari, Subrata Debnath, Xiao Ling Li, Bruna R. Muys, Young Song, Lorinc S. Pongor, Omar Sheikh, Andrew R. Green, Srinivasan Madhusudan, Ashish Lal, Stefan Ambs, Javed Khan, Mirit I. Aladjem, Sudha Sharma
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